Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids
نویسندگان
چکیده
Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.
منابع مشابه
Suppression of the neutral protease activity of macrophages treated with asbestos in vitro.
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 144 شماره
صفحات -
تاریخ انتشار 1976